Control of Industrial processes is very difficult due to nonlinear dynamics, effect of disturbances and modeling errors. M.Morari proposed Internal Model Control(IMC) system that can be effectively applied to the systems with model uncertainties and time delays. The advantage of IMC is their robustness with respect to a model mismatch and disturbances. But it is difficult to apply for nonlinear systems. ANFIS(Adaptive Neuro-Fuzzy Inference System) which contains multiple linear models as consequent part is used to model nonlinear systems. Generally, the linear parameters in ANFIS can be effectively utilized to control a nonlinear systems. In this paper, we propose new ANFIS-based IMC controller for nonlinear systems. Numerical simulation results show that the proposed control scheme has good performances.