Dynamic responses of a multi-span simply supported bridge are investigated to examine the effect of bearing damage under seismic excitations. The damaged bearings are modeled as sliding elements with friction between the superstructure and the top of the pier. Various values of the friction coefficients are examined to figure out the effect of damaged bearings with various levels of peak ground accelerations. It is found that the global seismic behaviors are significantly influenced by the occurrence of bearing damage. It should be noticed that the most possible location of unseating failure of superstructures differs from that in the bridge model without considering the bearing damage. It can be concluded that the bearing damage may play the major role in the unseating failure of a bridge system, so that the damage of bearings should be included to achieve more rational seismic safety evaluation.