This study contains the CFD analysis to predict the flow in engine room and utilize the results as a reference for arranging smoke detectors. FLUENT, a commercial CFD code is adopted because of its good application experience in DSME(Daewoo Shipbuilding & Marine Engineering Co.. Ltd.). The target is the engine room of VLCC. which was delivered in 2002. The model for analysis includes main structure elements, ventilation ducts, main engine and other big size equipment. From the analysis results, the internal flow pattern can be observed and some guidelines for the position of smoke detectors cane be presented.