In automotive industry, light weight vehicle is one of issues because of the air pollution and the protection of environment. Therefore, automotive manufacturers have tried to adopt light materials such as aluminum alloy to production line. Aluminum welding using laser has some advantages high energy density and high productivity. It is very important to understand weld characteristic according to welding condition in order to determine the possibility of application to car body. In this study, Nd:YAG laser welding of 5182 aluminum alloy with filler wire AA5356 was carried out through experimental design according to wire feed rate, laser power and welding speed. Weld bead shape in terms of cross section photo, bead with, height of reinforcement and penetration depth and mechanical property in terms of tensile strength and formability was investigated. Analysis of variation (ANOVA) was performed to know the effect of weld parameter for weldability, laser power was statistically most significance factor of three variables.