The purpose of this paper is to study of the attitude of e-learning on the effectiveness of e-learning and the antecedents of e-learning. For this study, samples were collected from students who had attended a cyber lecture at university. Structural equation model was used to analyze the data. The result of this empirical study is summarized as followings. First, the attitude of e-learning has a positive effect on the e-learning effectiveness. Second, ease of use of learning management system, learning motivation, information quality of learning contents has positive effect on the attitude of e-learning, but usefulness of learning management system has no effect on the attitude of e-learning. Therefore, the former consists of learning management system, learning contents and information quality that are provided by e-learning and the latter means learning motivation.