Objective : Allergic rhinitis is an allergic reaction characterized by sneezing, coughing, itchy nose, mouth and throat, congestion and/or nasal discharge. We aim to observe effect of Sinichengpae-um on protective effects of nasal mucosal tissue in th allergic rhinitis. Method : For this purpose, we oberserved number of leukocyte and erythrocyte in blood, ratio of neutrophil and lymphocyte in leukocyte, activity of GOT and GPT, and histopathologic change of nasal mucose. Result and Conclusion : Sinicheogpae-um showed effects on immune reaction with no harms liver. And in histopathologic change of nasal mucosal tissue, Sinichengpae-um showed significant protective effet against allergic rhinitis.