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Hepatoprotective Activity of Ethanolic Extract of Bacopa monnieri Linn. Aerial Parts Against $CCl_4-induced$ Hepatotoxicity in Rats
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  • Hepatoprotective Activity of Ethanolic Extract of Bacopa monnieri Linn. Aerial Parts Against $CCl_4-induced$ Hepatotoxicity in Rats
  • Hepatoprotective Activity of Ethanolic Extract of Bacopa monnieri Linn. Aerial Parts Against $CCl_4-induced$ Hepatotoxicity in Rats
저자명
Maity. Tapan Kumar,Dash. Gouri Kumar,Bose. Anindya,Nayak. Siva Sankar,Dash. Deepak Kumar,Ghosh. Tirtha
간행물명
Natural product sciences
권/호정보
2007년|13권 1호|pp.61-67 (7 pages)
발행정보
한국생약학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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The ethanolic extract of Bacopa monnieri Linn. aerial parts were studied far its hepatoprotective effect on $CCl_4-induced$ hepatotoxic rats. The extract was found to decrease significantly $CCl_4-induced$ elevation of SGOT, SGPT, ALP, bilirubin and total cholesterol. But, it increased HDL-cholesterol level and liver weight with respect to $CCl_4$ toxic rats. The extract was also found to decrease significantly the $CCl_4-induced$ elevation of lipid peroxidation and increase the activity of antioxidant enzymes (SOD and CAT) and GSH level in the liver of extract treated rats when compared with $CCl_4$ induced rats. Histopatholosical profiles showed that the extract had significant protective effect against $CCl_4-induced$ liver injury, which corroborates the above findings. Hence it may be possible that the mechanism of hepatoprotection of the extract is due to its antioxidant effect.