Within the framework of brake-by-wire technology, this paper presents five types of novel models of electro-mechanical disk brake calipers with self-servo mechanism which provides self-servo effect of boosting a friction force generated between the brake pad and the rotor disk surface. The models have been developed utilizing patent map analysis results of previous invents of electro-mechanical brake calipers. The feasibility of the developed motor-driven brake caliper models have been validated through the dynamic simulation analysis. Among the developed models, the caliper mechanism with separated pressure plate was designed especially in detail and was made as a pilot. The pilot caliper has been installed on the simple test bed constructed with domestic passenger car brake components, and its function and effectiveness have been validated through several types of experimental tests.