The balance shaft housing in the recent engines tends to have the high cycle fatigue crack caused by increased engine power. In this paper, a CAE procedure is introduced to predict the durability of the balance shaft housing. The procedure is performed through two analysis steps. In the first step, the multibody dynamic simulation is used to obtain more accurate loading boundary conditions applied to the finite element model for the following step. Next, the finite element analysis is performed to predict the durability of the balance shaft housing through the calculation of the safety factor. Through this CAE procedure, the revised balance shaft housing was developed to improve the durability. And the durability of the housing was confirmed experimentally.