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Preparation and Properties of Alginate/Polyaspartate Composite Hydrogels
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  • Preparation and Properties of Alginate/Polyaspartate Composite Hydrogels
  • Preparation and Properties of Alginate/Polyaspartate Composite Hydrogels
저자명
Lei. Jing,Kim. Ji-Heung,Jeon. Young-Sil
간행물명
Macromolecular research
권/호정보
2008년|16권 1호|pp.45-50 (6 pages)
발행정보
한국고분자학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

This study examined the swelling behavior and in vitro release of a model drug, tetracycline-HCl, from alginate and alginate-polyaspartate (Alg-PASP) composite gel beads. The alginate and Alg-PASP composite beads were prepared using an ionic crosslinking method with aqueous $Ca^{2+}$. Their microporous morphology was observed by scanning electron microscopy. The swelling ratio of the beads in different media varied according to their composition, cross-linking density ($Ca^{2+}$ concentration), and pH of the aqueous medium. The in vitro release experiment of the tetracycline-HCl encapsulated beads in different media suggests that the release of the drug is governed mainly by the swelling properties of the polymer network. The presence of PASP was found to significantly influence the swelling properties and drug release profile.