The paper investigates the seismic performance of a Partially-Restrained (PR) steel-concrete composite frame using the probabilistic approach. The analysed frame was tested at the ELSA laboratory of the Joint Research Centre of Ispra (Italy), while the representative beam-to-column composite connections were tested at the Universities of Pisa, Milan and Trento (Italy). The component modelling of both interior and exterior composite joints is described first, including the experimental-numerical validation. The Latin Hypercube method has been used to draw the probabilistic distribution curves of joints, and then the whole PR composite frame has been analysed. Pushover and incremental dynamic analyses have been carried out using the non-linear FE code SAP2000 version 9.1. The fragility and performance curves of the PR composite frame have been determined for four damage limit states.