A rational and efficient seismic design methodology for irregular space steel frames using advanced methods of analysis in the framework of Eurocodes 8 and 3 is presented. This design methodology employs an advanced static or dynamic finite element method of analysis that takes into account geometrical and material non-linearities and member and frame imperfections. The inelastic static analysis (pushover) is employed with multimodal load along the height of the building combining the first few modes. The inelastic dynamic method in the time domain is employed with accelerograms taken from real earthquakes scaled so as to be compatible with the elastic design spectrum of Eurocode 8. The design procedure starts with assumed member sections, continues with the checking of the damage and ultimate limit states requirements, the serviceability requirements and ends with the adjustment of member sizes. Thus it can sufficiently capture the limit states of displacements, rotations, strength, stability and damage of the structure and its individual members so that separate member capacity checks through the interaction equations of Eurocode 3 or the usage of the conservative and crude q-factor suggested in Eurocode 8 are not required. Two numerical examples dealing with the seismic design of irregular space steel moment resisting frames are presented to illustrate the proposed method and demonstrate its advantages. The first considers a seven storey geometrically regular frame with in-plan eccentricities, while the second a six storey frame with a setback.