The present paper focuses on the application of commercial acid dyes and wool reactive dyes to casein protein fabric. Nine acid dyes and six wool reactive dyes were compared their dyeing properties as well as color fastness. The exhaustion yields were higher than 80 % which dramatically increased at pH 3. Excellent wash fastness was obtained with metal-complex acid and wool reactive dyes. Both light and rubbing fastness were overall good, but perspiration fastness was comparatively poor.