In the present study, optimization of throttle margin for high pressure turbine to be retrofitted or partially modified for power uprating or life extension in nuclear power plant, has been performed to increase the electrical output. Throttle margin for high pressure turbine is required to maintain all the time the rated power by opening more of governor valves whenever inlet pressure is decreased due to the tube plugging of steam generator. If throttle margin of high pressure turbine is too much compared to remaining lifetime, loss of electrical output due to pressure drop of governor valves is inevitable. On the contrary, if it is too little, the rated power operation can not be accomplished when inlet pressure of high pressure turbine is dropped after many years operation. So, throttle margin for high pressure turbine in nuclear power plant is compromised considering for the degradation of steam generator, governor valve capacity, manufacturing tolerance of high pressure turbine, future plan of power uprating, and remaining lifetime of power plant.