Injection pressure is an important factor in filling procedure for injection molded parts. In addition, weldlines should be avoided to successfully produce injection molded parts. In this study, we optimally obtained injection molding process parameters that minimize injection pressure. Then, we determined the thickness of the part to avoid weldlines. To solve the optimization problem proposed, we employed MAPS-3D (Mold Analysis and Plastics Solution-3 Dimension), a commercial CAE tool for injection molding analysis, and PIAnO (Process Integration, Automation, and Optimization) as a commercial PIDO (Process Integration and Design Optimization) tool. We integrated MAPS-3D into PIAnO, automated the analysis and design procedure, and performed optimization by employing PQRSM (Progressive Quadratic Response Surface Method) equipped in PIAnO. We successfully obtained optimization results, which demonstrates the effectiveness of our design method.