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Serum anti-M$ddot{u}$llerian hormone levels as a predictor of the ovarian response and IVF outcomes
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  • Serum anti-M$ddot{u}$llerian hormone levels as a predictor of the ovarian response and IVF outcomes
  • Serum anti-M$ddot{u}$llerian hormone levels as a predictor of the ovarian response and IVF outcomes
저자명
Choi. Min-Hye,Yoo. Ji-Hee,Kim. Hye-Ok,Cha. Sun-Hwa,Park. Chan-Woo,Yang. Kwang-Moon,Song. In-Ok,Koong. Mi-Kyoung,Kang. Inn-Soo
간행물명
Clinical and experimental reproductive medicine
권/호정보
2011년|38권 3호|pp.153-158 (6 pages)
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대한생식의학회
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정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Objective: The aim of this study was to investigate whether anti-M$ddot{u}$llerian hormone (AMH) levels could be predict ovarian poor/hyper response and IVF cycle outcome. Methods: Between May 2010 and January 2011, serum AMH levels were evaluated with retrospective analysis. Three hundred seventy infertile women undergoing 461 IVF cycles between the ages of 20 and 42 were studied. We defined the poor response as the number of oocytes retrieved was equal or less than 3, and the hyper response as more than 25 oocytes retrieved. Serum AMH was measured by commercial enzymelinked immunoassay. Results: The number of oocytes retrieved was more correlated with the serum AMH level (r=0.781, $p$ <0.01) than serum FSH (r=-0.412, $p$ <0.01). The cut-off value of serum AMH levels for poor response was 1.05 ng/mL (receiver operating characteristic [ROC] curves/area under the curve [AUC], $ROC_{AUC}$=0.85, sensitivity 74%, specificity 87%). Hyper response cut-off value was 3.55 ng/mL $ROC_{AUC}$=0.91, sensitivity 94%, specificity 81%). When the study group was divided according to the serum AMH levels (low: <1.05 ng/mL, middle: 1.05 ng/mL - 3.55 ng/mL, high: >3.55 ng/mL), the groups showed no statistical differences in mature oocyte rates (71.6% vs. 76.5% vs. 74.8%) or fertilization rates (76.9% vs. 76.6% vs. 73.8%), but showed significant differences in clinical pregnancy rates (21.7% vs. 24.1% vs. 40.8%, $p$=0.017). Conclusion: The serum AMH level can be used to predict the number of oocytes retrieved in patients, distinguishing poor and high responders.