The dynamic stress of the diesel engine block is analyzed by using flexible-body dynamic analysis. Multiple loadings including the pressure load due to gas combustion, thermal load, and dynamic load are considered. Thermal load is assumed constant, however, pressure load and dynamic load are treated as time dependent. The present work is focused on the dynamic stress analysis, especially on finding critical points of the engine block. The analysis model includes four parts - engine block, generator, bed, and mounts. On the other hand, crank shaft, pistons, and main bearings are excluded from the model. However, their dynamic effects are applied by dynamic forces, obtained in the separate analysis. Dynamic stress is found by using flexible body dynamic analysis, and compared to the measured data.