This paper presents an optimal operation of microgrid systems and considering a tie-lines capacities that concerned each grid. The microgrid system consists of a wind turbine, a diesel generator, and a fuel cell. An one day load profile and wind resource for wind turbine generator were used for the study. For the grid interconnection, tie-line capacities were applied as constraints. The capacity constraints of tie-lines in production cost analysis are very important issues in the operation and planning of microgrid. In optimization, the Harmony Search (HS) algorithm is used for solving the problem of microgrid system operation which a various generation resources are available to meet the customer load demand with minimum operating cost. The application of HS algorithm to optimal operation of microgrid proves its effectiveness to determine optimally the generating resources without any differences of load mismatch.