This study investigated the antioxidant and antigenotoxic ability of different wheat aleurone (WA) extracts. Oxygen radical absorbance capacity (ORAC), which was the highest in the aleurone ethanol extract (AEE) and the lowest in the acetone extract (AAE), was highly correlated with total polyphenol content (r=0.897, p<0.01). DPPH radical scavenging activity was highest in AAE followed by AEE and the aleurone methanol extract (AME). The $ABTS^{{cdot}+}$ quenching properties of the WA extracts were similar to their DPPH radical scavenging activity. Furthermore, WA extracts had a protective effect against oxidative stress-induced DNA damage in both human leukocytes and HT-29 human colon carcinoma cells. This inhibitory activity was attributed to their unique phytochemical content, with a strong correlation between DPPH radical scavenging activity and inhibition of DNA damage (r=0.779, p<0.01 at 10 ${mu}g/mL$ AAE). Therefore, WA might be a promising component of future nutraceuticals or value-added products.