Purpose: The purpose of this study was to identify the effects on knowledge and performance confidence of nursing students in the emergency care of patients with dyspnea after simulation education using a human simulator. Method: The research design was a nonequivalent control group pretest-posttest design. For the experimental group the human simulator was used to provide simulation. Also included were base learning with audio-visual material, explanations about simulation, using SimMan for human simulation, and debriefing. Pre and post-tests were conducted to compare differences in knowledge and performance confidence. Result: The (t=3.83, p<.000) than the control group. For the experimental group, the differences in pretest-posttest scores for knowledge (t=2.30, p=.025) and performance confidence (t=4.28, p<.000) were significantly higher than the experimental group had significantly higher scores for knowledge (t=3.03, p=.004) and performance confidence (t=3.83, p<.001knowledge (t=2.30, p=.025) and performance confidence (t=4.28, p<.000) were significantly higher than the control group. Conclusion: The results of this study indicate that for student nurses, knowledge and performance confidence in emergency care of patients with dyspnea improve with human simulator simulation education. Further study is suggested to develop other scenarios for emergency care and identify the effects of critical thinking and satisfaction when using human simulator simulation education.