In this study, the reliability-based design optimization of the airfoil was performed. PARSEC function was used to consider the uncertainty of the aerodynamic shape for the reliability-based shape optimization of airfoils. Among various reliability analysis methods, the moment method was used to compute the probability of failure of the aerodynamic performance. The accuracy of the reliability analysis was compared with other methods and it was found that the moment method predicts the probability of failure accurately. Deterministic and reliability-based optimizations were performed for the shape of the airfoil and it was demonstrated that reliability-based optimum assures the aerodynamic performances under uncertainties of the shape of the airfoil.