The basic understanding of gas diffusion and technology to predict the diffusion phenomena are needed to prepare against a disaster of leakage of natural gas and to design better consistent and reliable gas supply system in enclosure. The experimental results of British Gas Technology Co. are used in present study as a reference of theoretical study using CFD. The present results of 2D CFD analysis for mass flow rate of nozzle release show good agreement with experimental results within 2.6 % error. 3D CFD analysis for the characteristics of natural gas diffusion in enclosure with various ventilation patterns also gives reasonable agreement with experimental results.