Purpose: The purpose of this descriptive study was to determine the perception of nurses on multicultural families. Methods: The study population consisted of 493 nurses from eight general hospitals in B city. Data collection was done from June 1 to July 31, 2012. The Perception for Multicultural Family Inventory developed by Jun and Kim (2010) was used as the study instrument. The collected data were analyzed by t-test and ANOVA using SPSS/WIN version12.0. Results: Perception of nurses for multicultural families was 3.64 points out of 5. Most of the nurses considered that multicultural education is necessary. However, there were only a small number of nurses received training on multiculturalism. Conclusion: The results of this study indicate that education and support on multiculturalism for nurses are needed to improve health related quality of life for the multicultural families.