In this paper, an alternative variable structure controller is designed for the point-to-point regulation control of uncertain general linear plants so that the output of plants can be controlled from an arbitrarily given initial point to an arbitrarily given reference point in the state space. By using the error between the steady state value of the output and an arbitrarily given reference point and those integral, a transformed integral sliding surface is defined, in advance, as the surface from an initial state to an arbitrarily given reference point without the reaching phase problems. A corresponding control input is suggested to satisfy the existence condition of the sliding mode on the preselected transformed integral sliding surface against matched uncertainties and disturbances. Therefore, the output controlled by the proposed controller is completely robust and identical to that of the preselected transformed integral sliding surface. Through an example, the effectiveness of the suggested controller is verified.