Objectives : The purpose of the study is to investigate the clinical practice stress reduction and to improve clinical practice satisfaction in dental hygiene students. Methods : The subjects were 354 dental hygiene students in Gwangju and Jeonnam. A self-reported questionnaire was filled out from June 3 to 21, 2013. The questionnaire included stress management in the clinical practice. Results : As for clinical practice stress, there was a significant relevance between satisfaction in major and clinical practice. Clinical practice stress coping had a significant relevance to clinical practice satisfaction and clinical practice stress. Conclusions : In order to reduce clinical practice stress in dental hygiene students and to enhance clinical practice satisfaction, it is important to develop clinical practice stress management program and to develop the appropriate measurement tool for stress.