Objectives : The purpose of this study was to examine the effect of self-resilience and self-efficiency on the satisfaction with major in dental hygiene students. Methods : The data were analyzed by the frequency analysis, one-way ANOVA, Duncan post-hoc analysis, correlation analysis, multiple regression analysis using SPSS 18.0. The subjects were 411 dental hygiene students in A University in Gyeongsangbuk-do and K-University in Gyeongsangnam-do from November 4 to 15, 2013. Results : The satisfaction with major in dental hygiene students showed the positive correlation with self-resilience and self-efficiency. Multiple regression analysis revealed the optimistic attitude towards the self-resilience and self-efficiency. The explanation power was 13%. Conclusions : The self-resilience and self-efficiency had a positive effect on the satisfaction with major. It is necessary to develop the program that can help increase the self-resilience and self-efficiency, and apply such program to the curricula.