The experimental and numerical studies of the single-phase flow pressure drop in parallel micro-channels were performed. The parallel micro-channels consisted of 15 channels with depth 0.2mm, width 0.45mm and length 60mm. The FC-72 was used as the working fluid and the mass fluxes ranged from 62.8 to $1371.6kg/m^2s$. The numerical analysis was performed iterative calculations to solve governing equations and finds the appropriate value. The experimental data was compared with the numerical data, the results showed good agreement with the numerical data.