Even though there has been consistent emphasis on the issues of applying knowledge of
the brain in education, not much change has been made in practical educational fields.
Based on the premise that understanding brain knowledge is a necessary condition for
teachers to apply brain-based education in class, the purpose of this study was to explore
pre-service teachers' interests in brain knowledge, their perspectives on the importance of
brain-literacy and the requisites for the application of brain-based education. The survey was
conducted by 521 pre-service teachers (269 elementary school pre-service teachers, 252
middle school pre-service teachers) and the results revealed that cognitive process was the
most interesting idea among pre-service teachers. Also, they responded that understanding
the brain could play a significant role in educational fields, especially in the diagnosis of
problems in learning and arranging education programs. In addition, the teachers reported
that the relevance of brain-based education to actual class is the most important part of the
application of brain-based education. The study indicates that the psychological basis for the
effective brain knowledge education programs for teachers have been established. For the
efficacy of brain-based education, the knowledge of cognitive process including learning and
memory should be provided to pre-service teachers and researchers and applied to the real
education system.