Purpose: This study was conducted to investigate the influence of major satisfaction and ego-resilience on nursing professional values of nursing students. Method: A descriptive design was used in this study. Data were collected from 226 nursing students by mean of self reported questionnaire about major satisfaction, ego-resilience and nursing professional values from June 15 to 30, 2016. Result: There were positive correlations between major satisfaction, ego-resilience and nursing professional values. The significant factors influencing nursing professional values of nursing students were major satisfaction and ego-resilience, which explained about 36.6%. Conclusion: Attention should be given to nursing education to cultivate nursing professional values by improving major satisfaction and ego-resilience in nursing students.