This study is a methodological research that sought to develop and apply a computer program and standard treatment guideline for the administration of patients suffering from an adverse reaction to contrast medium for Computed Tomography(CT). Our second goal was to improve the quality of safe nursing care service by preventing side effects during re-inspection through the systematic management of the data about the patients who are using contrast medium. As a summary of the present research, the computer program for the administration of patients suffering from an adverse reaction to contrast medium and the standard treatment guidelines for administration developed and applied in this research prove to be very effective in terms of providing a safe nursing care service. In particular, they contribute to the reduction of an adverse reaction rate among patients with a case history. Furthermore, using the developed patient registration program for CT scanning makes it possible to accumulate the information about both the patients who experience the first occurrence of an adverse reaction and those who have a case history after wards, the patients with a case history of an adverse reaction can be screened by the computer program. Radiology department nurses can reduce an adverse reaction through appropriate pre-treatment in accordance with the standard treatment guidelines before inspection. Further expected contributions of the results of our study include improvement of the quality of safe care service, hospitalization days enhancing cost effectiveness and efficiency of administration and computer management system, as well as boosting the quality of clinical decision making the EMR program.