The purpose of this study was to examine the effects of pre-delivery music therapy program on the reduction of anxiety and stress in pregnancy of the primigravidas. Subjects were 40 primigravidas who registered and visited in obstetrics and gynecology clinics of M hospital in Daejeon from January 10 to March 30 in 2006. They were randomly assigned into the two groups: the experimental group(n=20) and the control group(n=20). The data collected from 37 subjects(19 from the experimental group and 18 from the control group) were analyzed and 3 subjects who had delivery or did not participate in post-test were excluded. The experimental group participated in 40 minutes pre-delivery music therapy program once a week for 6 weeks, a total of 6 sessions with pre-delivery physical exercises, while the control group just participated in the pre-delivery physical exercises. The pre-delivery music therapy program consisted of various musical activities such as singing, songwriting, playing, lyric discussion and music listening. Moreover, this program included home-based, individually preferred music listening. To find out the changes in state anxiety, stress in pregnancy, and finger temperature each scale of both groups was administered before and after the 6 treatments. Independent t-tests were employed to compare the scores of the two groups. Results showed significant differences in the scores of state anxiety, stress in pregnancy, and finger temperature between the two groups. It is implied that the pre-delivery music therapy program can be useful as psychological intervention to decrease anxiety and stress which may occur during the period of pregnancy.