Since the concept of critical thinking has been widened to include both cognitive skills and affective dispositions, several empirical studies have begun to explore cultural differences in critical thinking. Although a few studies have shown cultural differences in critical thinking dispositions, very little empirical research has been conducted to examine cultural differences in critical thinking skills and critical thinking as a whole. And there are very little empirical studies to examine the processes using both skills and dispositions. Based on the assumption that critical thinking and self-regulation both have dispositional aspects as well as skills, the purpose of this study is to explore cultural differences in the processes though skills and dispositions in terms of self-regulation among American, Korean-American, and Korean students, and to extend the differences in critical thinking. As a result, there were no significant differences in self-regulation among the three different cultural groups. In terms of the seven processes on self-regulation, however, differences among the three different cultural groups were found and the difference was revealed by the interaction between culture and gender among the three different cultural groups. It means that there would be possibility to say that the differences in thinking across cultures might be a matter of applying, not different ability. This study would have the potential of being helpful in showing what role cultures themselves play on the relationship between skills and dispositions, understanding how extensive the differences actually are.