This study aims to explore the area and levels of care-givers’ worries about guardianship for individuals with developmental disabilities and to examine the relationships between the levels of care burden and worries about guardianship among care-givers. For these purposes, descriptive data analyses and structural equational modeling(SEM) were performed involving 1,498 individuals participated in the National Survey on Supportive Service Needs Assessment for Individuals with Developmental Disabilities. Concerning the results of descriptive analyses on care-givers’s worries, financial burden and preparation for guardianship were relatively higher, wheres violation of consumers’ human rights was relatively lower. Regarding the results of SEM, care-givers with higher levels of care burden reported higher levels of worries about guardianship. Specifically, care burden was positively related to worries about proper guardian availability, health and medical issues, housing, and preparation for guardianship. Care burden was not significantly associated with violation of human rights, asset protection, and financial burden. Based on these results, implications were discussed for the future directions of the guardianship for individuals with developmental disabilities.