The purpose of this case study is to examine the therapeutic changes of working women who suffer from psychological exhaustion through human-centered art therapy for self-care. Participants in the study were working women in their early 30s who complained of exhaustion symptoms such as lethargy, decreased motivation, and atrophy of self-expression due to stress at work. A total of 14 art therapy sessions were conducted once a week for 60 minutes. For the study, the results of pre- and post-HTP picture tests were compared. The process of changes by session, changes in art work and daily life, and changes in self-care behavior were qualitatively analyzed for all treatment journals, treatment works, and vocabulary. As a result of the study, first, lethargy and stress were reduced, making work life less difficult and returning to a healthy daily life. Second, there was a change in self-actualization by practicing daily actions for self-care, including meals. Third, self-confidence and interpersonal relationship changes were shown in comparison of the pre- and post-HTP picture tests. This study is meaningful in qualitatively showing the changes through art therapy by examining the therapeutic changes of working women who experience burnout through human-centered art therapy for self-care. Based on these research results, the significance and limitations of this study were discussed.