Mid–life transition occurs during the middle of the first half of life to the second half of life, and there is a noticeable psychological change. This research is about the life–structure changes of mid–life transition women and neurosis that arises during their revaluation period, neurosis in middle age can be understood as the suffering of a human being who has not yet discovered what life means for them. This dissertation has its chief focus on ‘gender splitting’ as the primary element of neurosis. Neurosis in middle age shows religiosity, so this research discussed the religious dimension of neurosis through study on the pathological anxiety of Tillich’s point of view. This study is based on Levinson’s research regarding women during the mid–life transition, reinterprets women’s neurosis from psychological and sociological dimensions, which is comparable to the concept of neurosis of Jung, and look for religious aspects of neurosis through the concept of Tillich’s pathological anxiety. Although neurosis is a painful experience, to find out the meaning of life in the hidden side of neurosis and maintain psychological balance, can be a chance for personal development.