The purpose of this study was to examine the relationship between perceived social support, self-efficacy and depression in female college students. The data were collected from 183 female students residing in G city and analysed. The data were analysed through t-test, pearson correlation coefficient and stepwise multiple regression analysis. The result indicated that influence of two perceived social support subscales(family support, professor support) and two self-efficacy( self-regulation, confidence). Significant negative correlation were observed between self-efficacy and depression, between social support and depression. The variables of depression in female college students were self-efficacy and social support each explained 12.1%, 11.3% of the cases. These results implicate that differential intervention is needed in college counseling for female college students depression. Therefore it's needed to develop nursing intervention programs to promote self-efficacy and social support.