Fourtyone patients of gallbladder and bile duct diesases were studied clinically and sonographically. Tweentynine (Seventyone percent) patients were distributed between age fourty to fiftynine and male to female ratio was 1 : 1.4. The order of frequency of biliary tract disease was cholelithiasis, acalculous cholecystitis, CBD stone and CBD cancer. Sonographic findings of cholelithiasis were strong echo with posterior shadowing, faint internal echoes without shadowing, gallbladder wall thickening and anechoicity of the gallbladder wall. Instead of small proportion of gallbladder distension and wall anechoicity, faint internal echoes without shadowing were seen in ten of nineteen cases of cholelithiasis. On choledocholithiasis, meniscus sign at the junction of the stone and gallbladder wall was identified in most cases and was helpful to differentiation stone from malignancy. The degree of CBD dilatation was more severe in malignancy than in CBD stone and ascaris in CBD. Sonographic examination was useful in detection of gallbladder and bilicary tree pathology and the cause of biliary tract obstruction could be identified.