Recently, interest in climate change is growing in school education and there are many educational programs to help students aware of the magnitude of climate change and enhance their practice will to cope with the climate change. However, many of them is done as one-off event or limited to deliver shallow knowledge of climate change. Thus, this study aims to develop a brain-based learning program for climate change, which intends to stimulate affective domain of students, and to enable them to do actions to cope with the climate change. The researchers analyzed science textbook related to ecological system, organism and environment presented in the first semester of the sixth grade, and interviewed science teachers. As well, the researchers developed an educational program dealing with environmental pollution and destruction of ecological systems, following the brain-based evolutive learning. This study will give some implications for climate change education. First, the brain-based approach adopted in this study may give some clues for climate change education appropriate for primary level. Second, the developed program will help students to enhance their interests in and creativity about climate change and finally lead them to be involved in practices for climate change. Climate change education should bring about students’ change about attitude toward climate change and their practice will as well as the better understanding of climate change. The focus should be more put on the improvement of students about awareness of and attitude toward climate change.