Purpose: Delirium is one of the symptoms that occur to hospitalized elderly patients, resulting in temporary changes in brain function and adeterioration in quality of life. The increasing number of elderly patients in hospital suggests that there is a need for delirium prevention nursing to provide hospitalized elderly patients with psychological, physical and environmental care. Result: The role of nurses who have the most contact with patients is important and the success of care depends on whether or not the application of care suits the demands of actual clinical situations. Nursing care for delusion disorder is intended to primarily eliminate the causes of nursing and help patients recover. For delirium prevention nursing, nursing care should involve treating illness, helping patients maintain time-person-place orientation, improving their orientation, minimizing unnecessary stimuli and noise, remove unnecessary catheters, pain control, sleeping maintenance and helping them spend more time with familiar people. Conclusion: Nursing elderly patients should be focused on understanding the physical, psychological, environmental and social conditions of elderly patients and providing them comfort. Nurses need a variety of education to understand elderly patients, delirium assessment tool for elderly delirium prevention should be appropriately evaluated by clinical application. Further more, it is important to provide care for patients with delusion at the same time they are hospitalized to produce better results rather than nursing patients with advanced delirium.