This study presents an investigation teaching syllabus and teaching materials that are needed to develop and utilize a curriculum for students with severe or multiple disabilities. The teaching syllabus needed for developing investigation teaching and learning materials were made based on basic research developed by the National Institute of Special Education (2013), and there are four detailed area: basic investigation, perception, living mathematics, and living science. The writing details for basic investigation were structured based on interest, exploration, memory, and distinction. As for the scope of perception, the writing details were structured according to shape perception and space perception. For living science, the writing details were structured according to body, animals and plants, tools, nature, and the environment. Each unit was developed for different schools according to the students’ age, using similar subject matter. The content validity was verified through discussion amongst professionals, and it was verified two times through four steps that included a review of the writing details, verification of the manuscript, verification of the rewritten manuscript, and verification of the edited manuscript. External consultants examined the contents, and a Delphi survey was also conducted. The final developed units consisted of 18 units on basic investigation, 17 on perception, 17 on living mathematics, and 19 on living science. In the future, in order to develop and make use of a school curriculum in the investigative field for students with severe or multiple disorders, firstly a hierarchical selection of curriculum should be made according to their level of disability and capability as an alternative education curriculum. Secondly, an integrative curriculum based on everyday life should be presented, and thirdly, there needs to be activity-based content that could stimulate the five senses and arouse the interests of the students. Moreover, in order to utilize such a curriculum, content of a consistent and high level of overall support needs to be included within the IEP. This study also discusses the need to come up with teaching and learning materials that support the instructors in their lessons.