당뇨병 유무에 따른 뇨 나트륨 배설량과 복부비만과의 상관관계

서지반출

국문초록

본 연구는 한국 성인을 대상으로 당뇨병 유무에 따른 뇨 나트륨 배설량과 복부비만과의 연관성을 분석하고자 하였다. 2010-2011년 국민건강영양조사에 참여한 만 30세 이상 성인 총 8,948명을 대상으로 공복혈당에 따라 1) 정상군, 2) 전당뇨병군, 3) 당뇨병군으로 분류하였다. 나트륨 섭취량은 정상군과 전당뇨병군에서 뇨 나트륨 배설량과 유의적인 양의 상관관계를 가졌다. 또 한, 전당뇨병군에서 뇨 나트륨이 증가함에 따라 허리둘레가 유의적으로 증가하였고, 교란 변수들을 보정한 후 뇨 나트륨 배설량이 증가할수록 복부비만 발병 위험이 유의적으로 높아졌다. 전당뇨병 대상자 중 뇨 나트륨 배설량이 높은 군에서 당뇨병 관련 인자 인 공복 인슐린, homeostasis model assessment of insulin resistance이 증가함에 따라 복부비만 발병 위험이 유의적으로 높은 것으 로 나타났고, 이러한 유의성은 교란 변수들을 보정한 후에도 유지되었다. 결론적으로, 전당뇨병 성인에서 고 나트륨 섭취는 허리 둘레를 증가시켜 인슐린 저항성과 제2형 당뇨병 발병 위험을 높이는데 기여할 것으로 사료된다. 따라서 나트륨 섭취량이 권고 수 준보다 높고 제2형 당뇨병의 잠재적 위험군인 한국의 전당뇨병인을 대상으로 실질적으로 나트륨 섭취를 줄일 수 있는 전략과 교 육이 필요하다고 제안한다.

영문초록

The objective of this study was to investigate whether urinary sodium is associated with the prevalence of abdominal obesity in Korean adults. Study population consisted of a total 8,948 adults(older than 30 years old) who participated in the Korea National Health and Nutrition Examination Survey V-1 and V-2 conducted in 2010 and 2011. Subjects were divided into three groups according to fasting blood glucose: 1) normal, 2) pre-diabetes and 3) diabetes. Dietary sodium intake was significantly correlated with urinary sodium excretion in normal and pre-diabetes groups. Also, urinary sodium was positively associated with waist circumferences(WC) in pre-diabetes. After adjusting for potential confounders, urinary sodium in second and third tertiles was associated with abdominal obesity in the pre-diabetes(odds ratio(OR) for second tertile=1.499, p=0.010 and OR for third tertile=1.556, p=0.003). The ORs for abdominal obesity was significantly elevated per incremental increases in fasting insulin and homeostasis model assessment of insulin resistance(HOMA-IR) in pre-diabetes with high levels of urinary sodium excretion. Further, these associations remained even after adjusting for confounding factors. These results suggest that diet with high sodium content may have a negative influence on the progression of insulin resistance and type 2 diabetes by increasing WC in pre-diabetic adults. Therefore, strategy and education to reduce sodium intake will be necessary for the pre-diabetic Korean adults.

키워드

abdominal obesity pre-diabetes urinary sodium

참고문헌 (41건)

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