Increasing interest in computer-mediated learning technologies has prompted educators to incorporate them into many learning environments ; however, there is still little evaluative evidence to support their effectiveness. This report describes the development and evaluation of a web-based instructional program on basic nursing science for nursing students. Researcher-designed questionnaires were used to assess the characteristics of our students, and to solicit their ratings of the instructional program on ease of use, accuracy of content, clarity of content, interest, and convenience of the program, using 5-point Likert scales. The respondents indicated that the package was easy and convenient to use, with high technical Quality, and of a level challenging to some but not all of the students. On-line quizzes were most highly rated. Also it was confirmed that frequent users of electronic bulletin board showed much higher achievement score than that of nonfrequent users. It was also found that the effect of cyber education was dependent on the active participation of the students. These data suggest that the use of web-based instructional program as a distance education strategy can be an effective method for nursing students and nurses.