The purpose of this study was to assess secondary pre-service teachers’ multicultural efficacy. The researcher interpreted and revised the Multicultural Efficacy Scale developed by Guyton and Wesche for collecting data. The survey was composed of three sub-categories: experience, attitude, and efficacy. The number of participants in this study were 397 college students in secondary teacher education programs. Two statistical methods, correlation analysis and multiple regression analysis were adopted for data analysis. Research questions are as follows: First, what are secondary pre-service teachers' levels of attitude and efficacy? Second, what is the relationship between experience, attitude, and efficacy of secondary pre-service teachers? Results included: First, pre-service teachers participating in this study fell into the middle level range of attitude and high levels of efficacy. By utilizing categories by Choi and Mo, the researcher also thoroughly investigated results from each sub-scale of efficacy including general efficacy, efficacy in instructional competences, efficacy in caring perspectives, and efficacy in helping minority families and children. Results showed that the level of efficacy in instructional competences was lower than the efficacy in the other three areas. Second, experience and attitude were predictors in multicultural efficacy. The final part of this article included a discussion of findings compared with prior research. By utilizing findings in this study, the researcher discussed implications on teacher education curriculum.