The purpose of this study is to investigate the influences of multiple-role commitment on the subjective well-being of lifelong learners, and analyzed the moderate influences of self-regulatory efficacy. The cases of 522 from lifelong learners were used for this empirical study. The results of this empirical study exhibit that 1) multiple-role commitment has significant positive influences on the negative-positive affectivity(β=.48, p<.001), and job satisfaction(β=.41, p<.001), 2) learner's role commitment has significant positive added influences on negative-positive affectivity(△R2=.013, p<.05) and life satisfaction(△R2=.013,p<.05), even after controlling for the work role commitment, spouse role commitment, parent role commitment, 3) and self regulatory efficacy has a moderate influences on life satisfaction(△R2=.023, p<.01), but not negative-positive affectivity. This study was to examine whether multiple-role commitment of lifelong learners had positive or negative influences on the quality of life of them. This study verified that commitment in multiple roles provided rewards to lifelong learners by generating synergies among multiple roles.